Adult 150-600 mg daily given in 2 or 3 divided doses.
Neuropathic pain Initially 150 mg daily. May be increased to 300 mg daily after 3-7 day interval. Max dose: 600 mg daily after an additional 7-day interval.
Generalized anxiety disorder 150-600 mg daily given in 2 or 3 divided doses. Initially 150 mg daily. May be increased to 300 mg daily after 1 wk, then 450 mg daily following an additional wk. Max dose: 600 mg daily after an additional wk.
Epilepsy Initially 150 mg daily. May be increased to 300 mg daily after 1 wk. Max dose: 600 mg daily after an additional wk.
Fibromyalgia 300-450 mg daily given in 2 divided doses. Initially 75 mg bid & may be increased to 150 mg bid w/in 1 wk. May be further increased to 225 mg bid. Max dose: 600 mg daily after an additional wk.
Renal impairment w/ CrCl >60 mL/min Initially 150 mg daily, may be increased to 300 mg daily, then further increased to 450 mg daily up to max of 600 mg daily. All doses should be given in 2-3 divided doses;
30-60 mL/min Initially 75 mg daily, may be increased to 150 mg daily, then further increased to 225 mg daily up to max of 300 mg daily. All doses should be given in 2-3 divided doses;
15-30 mL/min Initially 25-50 mg daily, may be increased to 75 mg daily, then further increased to 100-150 mg daily up to max of 150 mg daily. All doses should be given in 1-2 divided doses;
<15 mL/min Initially 25 mg daily, may be increased to 25-50 mg daily, then further increased to 50-75 mg daily up to max of 75 mg daily. All doses should be given as single daily dose.
Patient receiving hemodialysis Initially 25 mg as single additional dose up to max of 100 mg as single additional dose following every 4 hr hemodialysis.
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